Adam (Joseph Gordon-Levitt) has a pretty good life. He works in Seattle as a producer for a public radio station, his best friend Kyle (Seth Rogen) is always good for a laugh, he lives happily with his girlfriend Rachael (Bryce Dallas Howard), and best of all, he’s exceptionally healthy. An odd back pain sends Adam to the doctor where he discovers he’s suffering from a late stage tumor. The diagnosis shocks him at first as he’s spent considerable time exercising, eating healthy, and avoiding alcohol and drugs, but he quickly moves to anger…because he’s spent considerable time exercising, eating healthy, and avoiding alcohol and drugs. His tumor is a rare type, and while he weighs his options including chemotherapy and surgery he discovers the unofficial odds on his survival over the next few months are fifty-fifty. There’s a one in two chance he’ll be dead before his next birthday. That pretty good life soon collapses around him as he’s forced to face the reality of both his life and death. His journey will expose certain truths about himself, his family and friends, and even a few strangers, and it might even give him a new pick-up line for the ladies… Imagine if Funny People was a comedy. Then imagine it was filled with wit, heart, and an honesty about the relationships we form throughout our lives. Now stop imagining, because that movie you’re picturing is 50/50.

Striking a balance between humor and humility is one of the toughest things to do in any form of storytelling, but just with this trailer, director Jonathan Levine and a cast that includes Joseph Gordon-Levitt, Seth Rogen, and Anna Kendrick look like they’ve done just that. Plus, they’ve done it while mocking the big baddie of the disease world. Formerly titled I’m with Cancer, 50/50 is a title that keeps the odds of the main character living front and center (even if they basically spoil that point in the opening part of the trailer), and the rest is filled with heads being shaved with questionable trimmers, therapy sessions, and foolish attempts at cancer-based pick-up lines.

According to a Summit Entertainment press release, Joseph Gordon-Levitt has replaced James McAvoy as the lead in the untitled dramedy formally known as I’m With Cancer. Gordon-Levitt will now play Adam, a young man diagnosed with cancer who must navigate the scary and confusing process of treatment. McAvoy’s reason for leaving? “He has left the production due to unrelated circumstances beyond his control”.

The future isn’t so “up in the air” for Golden Globe nominee Anna Kendrick, nor is it whack for The Wackness director Jonathan Levine.

Guess what little ones, cancer is hilarious!! Variety reports that undeniably Scottish actor James McAvoy has jumped on the cancer bandwagon with his attachment to I’m With Cancer.