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What is it with Owen Wilson and movies about dogs? Last year, Wilson joined Jennifer Aniston in the heart string-yanking, super-melodramatic dying dog movie Marley and Me, and now THR is reporting that he’ll be voicing the rascally Great Dane Marmaduke on the big screen.

Based on the popular comic strip that was created in 1954 by Brad Anderson and Phil Leeming, with a script by Tim Rassmussen and Vince Di Meglio (License to Wed, Smother), this live-action/CG movie will follow a family named the Winslows who move from Kansas to Orange County with their dog Marmaduke, a slobbery pooch who creates chaos wherever he goes. It will see the title character “navigate a volatile Mutts vs. Pedigrees turf war, woo the purebred of his dreams and overcome a fall from grace.”

Tom Dey (Failure to Launch, Shanghai Noon) will direct the feature, with Judy Greer, Lee Pace and William H. Macy making up the human cast. The other dogs in the story will be voiced by Fergie, Emma Stone, George Lopez, Christopher Mintz-Plasse, Steve Coogan, Damon Wayans and Marlon Wayans.

Sounds like a mix between Cats & Dogs and just about every other damn dog movie we’ve ever seen. Should make for a riveting cinematic adventure…